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Classification of cytotoxic drugs according to their potential to cause serious necrosis when extravasated

Please note that the groupings have been reversed as of October 2005 - this is in order to facilitate the formulation of a grading system for extravasation risk - the higher the grouping, the higher the risk of causing severe and serious tissue damage.

Neutrals:

Group 1

Inflammitants:

Group 2

Irritants:

Group 3

Exfoliants:

Group 4

Vesicants:

Group 5

Asparaginase

Etoposide Phosphate

Carboplatin

Aclarubicin

Amsacrine

Bleomycin

Fluorouracil

Etoposide

Cisplatin

Carmustine

Cladribine

Methotrexate

Irinotecan

Daunorubicin Liposomal

Dacarbazine

Cyclophosphamide

Raltitrexed

Teniposide

Docetaxel

Dactinomycin

Cytarabine

 

 

Doxorubicin Liposomal

Daunorubucin

Edroclomab

 

 

Floxuridine

Doxorubicin

Fludarabine

 

 

Mitozantrone

Epirubicin

Gemcitabine

 

 

Oxaliplatin

Idarubicin

Ifosfamide

 

 

Topotecan

Mitomycin

Melphalan

 

 

 

Mustine

Pentostatin

 

 

 

Paclitaxel

Rituximab

 

 

 

Streptozocin

Thiotepa

 

 

 

Treosulfan

Beta-Interferons

 

 

 

Vinblastine

Aldesleukin (IL-2)

 

 

 

Vincristine

Trastuzemab

 

 

 

Vindesine

 

 

 

 

Vinorelbine